IKK2 hepatocyte specific deletion alters cell cycle progression during liver regeneration

Aims: The liver is the only organ able to restore its mass and function after liver injury. NF-kB is involved in many cellular responses. In non-stimulated cells, NF-kB is sequestred in the cytoplasm by the inhibitory protein IkB. Upon stimulation, IkB is phosphorylated by the IKK complex, allowing NF-kB activation and translocation in the nucleus. The IKK complex consists of two catalytic subunits IKK1 and IKK2, and the regulatory subunit NEMO. Aim: We studied the impact of hepatocyte-specific IKK2 deletion on liver regeneration as NF-kB is involved in early events of hepatocyte proliferation. Methods: IKK2 con…