The role of E-type cyclins in liver regeneration and fibrogenesis

Introduction: The current understanding of cell cycle regulation in mammals has completely changed as recent studies demonstrated that the E-type cyclins E1 and E2 are not essential for cell proliferation per se, but for transition of quiescent cells into the cell cycle. Aims: To investigate the role of E-type cyclins during liver regeneration and c-myc induced liver disease. Methods: Partial hepatectomy (PH) was performed in cyclin E1 and E2 knockout (KO) mice and wildtype (WT) controls. Regeneration was monitored measuring the liver/body weight ratio after PH and established cell cycle markers for G1, S and M-…