Characterization and evaluation of hepatotropic targeting properties of xeno- or allogenic erythrocyte ghosts in normal and injured rat livers

Aims: Acute and chronic liver injury are accompanied by an invasion of monocytes and by an enlargement of the macrophage pool due to proliferation of Kupffer cells (KC) which secrete multiple mediators. Vesical carriers, e. g. liposomes or erythrocyte ghosts (EG) with encapsulated appropriate drugs might be a promising tool to modulate their paracrine influences on pathogenetic reactions, such as cell damage and fibrogenesis, if efficient and highly specific uptake is guaranteed under disease conditions. Aim: Comparison of organotropic, in particular KC targeting properties of xenogenic (human) and isogenic (rat…