Low-density lipoprotein receptor polymorphisms are associated with spontaneous and treatment-induced recovery from hepatitis C virus infection
T Müller, A Mas Marques, C Sarrazin, M Wiese, J Halangk, H Witt, E Schott, V Weich, B Schlosser, A Bergk, U Spengler, F Lammert, H Wasmuth, E Schreier, B Wiedenmann, T Berg · Zeitschrift für Gastroenterologie · 2008 · Heft 01
Bibliografische Angaben
Zusammenfassung
BACKGROUND/Aims: Low-density lipoprotein receptors (LDLR) have been determined candidate receptors for infectious Hepatitis C Virus (HCV) particles bound to host lipoproteins. LDLR-mediated binding and cellular uptake of these “lipo-viro particles“ (LVP) might be regulated by hepatocellular LDLR expression and competition between virus-free host lipoproteins and LVP for free LDLR binding sites. Since LDLR single nucleotide polymorphisms (SNPs) have been shown to interfere with the host lipoprotein metabolism, they might also affect the outcome of HCV infection. We therefore wanted to determine whether host LDLR…
