Comparison of the anti-cancer and anti-inflammatory properties of willow bark extract STW 33-I (Proaktiv®) with Aspirin® and Diclofenac

NSAIDs are well known by their anti-inflammatory effects, where inhibition of NFκ-B is a central anti-inflammatory mechanism and by their anticancer effects via cyclooxygenases (COXs) inhibition. The polyphenol- and salicin-rich willow bark extract STW 33-I (water extract, 16–23:1) is successfully applied in the treatment of painful and inflammatory diseases. The aim of this study was to determine anticancer and anti-inflammatory effects of STW 33-I and its polyphenolic fraction E (Fr. E) compared to well characterized NSAIDs such as Aspirin (ASS) and Diclofenac. The antiproliferative effect of STW 33-I on undif…