Classical Neurotransmitters involved in Major Depression

In major depression, hypoactivity of the mono-amines serotonin, noradrenaline and dopamine can be found in the midbrain. This is mostly caused by polymorphisms of the serotonin, norepinephrine or dopamine transporter genes. Moreover, two presynaptic inhibitory neurotransmitters gamma-aminobutyric acid (GABA) and glutamate are involved in pathophysiology of the disease, these neurotransmitters show hypo- and hyperactivity in some brain regions. In treatment of major depression, selective serotonin or noradrenaline reputake inhibitors or dual-binding antidepressants are administered. The different antidepressants…