Neurolymphomatosis with subacute sensorimotor polyneuropathy as first sign of non-Hodgkin B-cell-lymphoma

Objective: Neurolymphomatosis has been described by Lhermitte and Trelles in 1934. Since then, about 60 patients have been reported with the diagnosis made at autopsy in the majority of cases. Results: We report on a 65-year old and otherwise healthy patient with subacute (within 2 weeks) painful sensorimotor polyneuropathy with distal leg muscle palsy and bilateral subcutaneous edema of both legs. The initial complaint was a burning pain of both legs increasing in the night. Serological abnormalities were raised CRP (97.3mg/l) with normal procalcitonin, slight lymphocytosis (12.400/nl), positive cryoglobulins,…