Resting-State Synchronisation in Hepatic Encephalopathy

Objective: Hepatic encephalopathy (HE) is a complication occurring within patients suffering from cirrhosis of the liver. HE is characterised by a variety of cognitive and motor deficits. Previous studies demonstrated that motor symptoms like mini-asterixis at high grade HE arise from a pathologically slowed drive of the primary motor cortex towards the muscles and the thalamus. Furthermore, higher HE-grades lead to a gradual reduction in the critical flicker frequency (CFF), a measure for perception of oscillatory visual stimuli. Thus, CFF appears to be a sensitive and reliable diagnostic tool for classificatio…