CareLit Fachartikel
Role of NOV and CTGF in PDGF and TGF-β signaling in hepatic fibrogenesis
W Bohr, P Alexi, E Borkham-Kamphorst, R Weiskirchen · Zeitschrift für Gastroenterologie · 2010 · Heft 01
Dokument
1015063
CareLit-ID
Jahr
2010
Publikation
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Metadaten
DOI
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Zusammenfassung
Aims: CYR61 (CCN1), CTGF (CCN2) and NOV (CCN3) belong to the CCN protein family. They share a modular structure with a secretary signal peptide, an insulin-like growth factor binding protein-like domain, a von Willebrand factor type C and a Thrombospondin type-1 repeat module and a cysteine knot containing module. These cysteine-rich proteins are secreted and play an essential role in fibrogenesis [1]. Recently it was demonstrated that NOV and CTGF appear to act in a Yin/Yang manner to regulate extracellular matrix (ECM) metabolism [2]. Here we aimed to analyse the synergy of CTGF and TGF-β in the regulation of…
Schlagworte
CCN proteins
GRX
TGF-β signaling
hepatic stellate cell lines
proliferation
protein purification
Zeitschrift für Gastroenterologie
