Cannabinoid receptor type 1 expression modulates alcohol-induced liver fibrosis: Role of Acetaldehyde
E Patsenker, TT Wissniowski, G Millonig, S Mueller, HK Seitz, M Stoll, M Ocker, F Stickel · Zeitschrift für Gastroenterologie · 2010 · Heft 01
Bibliografische Angaben
Zusammenfassung
Aims: The endocannabinoid system is implicated in the regulation of hepatic fibrosis, steatosis and inflammation upon binding of either endo- or exocannabinoids to cannabinoid receptors (CBR)1 and 2. Daily cannabis smoking is a risk factor for fibrosis progression in chronic hepatitis C and a mediator of experimental alcoholic steatosis. The aim of the present study was to elucidate the expression and function of CBR in alcoholic liver fibrosis (ALF). Methods: 56 paraffin-embedded and 24 frozen liver tissues from patients with ALD were analyzed for CBR expression by immunohistochemistry (IHC) and mRNA levels. In…
