Lipid droplet-associated PAT-proteins show frequent and differential expression in neoplastic steatogenesis
BK Straub, E Herpel, S Singer, LM Pawella, R Zimbelman, K Breuhahn, S Macher-Goeppinger, A Warth, J Lehmann-Koch, T Longerich, H Heid, P Schirmacher · Zeitschrift für Gastroenterologie · 2010 · Heft 01
Bibliografische Angaben
Zusammenfassung
In many human cancers, lipogenic pathways are activated; in some tumors, such as hepatocellular carcinoma (HCC), this is reflected by the presence of visible lipid droplets (LDs). Yet, the biology of steatogenesis in malignant tumors is largely unknown. We have recently demonstrated that LD-associated proteins of the PAT-family, named after their constituents perilipin, adipophilin, and TIP47, are differentially expressed in hepatic steatogenesis. We have comprehensively investigated PAT-expression in neoplastic steatogenesis as well as in respective normal tissues with immunohistology and electron microscopy as…
