CareLit Fachartikel
Potent antifibrotic activity of mTOR inhibitors Sirolimus and Everolimus but not of Cyclosporine A and Tacrolimus in experimental liver fibrosis
E Patsenker, M Ledermann, H Saegesser, V Schneider, F Stickel · Zeitschrift für Gastroenterologie · 2010 · Heft 01
Dokument
1015077
CareLit-ID
Jahr
2010
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig
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Zusammenfassung
Aims: Recurrence of chronic hepatitis C (CHC) and progressive fibrosis in liver transplants impairs graft and patient survival. Recent evidence suggests that calcineurin inhibitors such as cyclosporine A exert antiviral effects, while others, such as sirolimus, may have antifibrotic properties. However, it is unclear whether the choice of immunosuppressant affects the course liver graft fibrosis. The aim of the present study was to compare established immunosuppressants regarding their potential to halt fibrosis progression in vivo. Methods: To induce fibrosis, 50 male Wistar rats underwent bile duct ligation an…
Schlagworte
cyclosporin A
everolimus
immunosuppression
liver fibrosis
liver transplantation
sirolimus
tacrolimus
Zeitschrift für Gastroenterologie
