The liver promotes antigen-specific clearance of naïve CD8+ T cells activated in situ
V Benseler, A Warren, LE Holz, M Vo, D LeCouteur, A Allison, N van Rooijen, HJ Schlitt, DG Bowen, GW McCaughan, P Bertolino · Zeitschrift für Gastroenterologie · 2010 · Heft 01
Bibliografische Angaben
Zusammenfassung
The liver has unique immunological properties as transplants are accepted in many animal models and infections of the liver (e.g. Hepatitis C virus) often become chronic. Although several hypothesis have been proposed, the mechanisms for the liver tolerance effect still remain unknown. Methods: Naive CD8+ Des-TCR transgenic T cells (H-2k) specific for the MHC class I H-2Kb were adoptively transferred into B6 (H-2b), which express the antigen ubiquitously, or B10.BR (H-2k) mice as negative controls. The cells were tracked using gamma counting, flow cytometry, confocal and electron microscopy. Results: Most radioa…
