CareLit Fachartikel

Polygenic background of dyslipidemia in obese children

C Breitling, P Büttner, D Schleinitz, S Blüher, W Kiess, P Kovacs, A Körner · Diabetologie und Stoffwechsel · 2010 · Heft 04

Dokument
1015500
CareLit-ID
Jahr
2010
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Diabetologie und Stoffwechsel
Autor:innen
C Breitling, P Büttner, D Schleinitz, S Blüher, W Kiess, P Kovacs, A Körner
Ausgabe
Heft 04 / 2010
Seiten
–
Erschienen: 2010-04-21 00:00:00
ISSN
1861-9002
DOI
10.1055/s-0030-1253974

Zusammenfassung

Recent Genome-wide association (GWA) studies identified several polymorphisms associated with alterations in lipid metabolism in adults. Based on these findings, we aimed to analyze new lipid modulating genes associated with the polygenic background of obesity and dyslipidemia in children, a population that is less affected by comorbidities or medication. A cohort of 1966 children was characterized for anthropometrical data (age, sex, BMI SDS etc.) and pubertal state. Of these, 815 subjects were overweight or obese (BMI SDS≥1.23), 1151 subjects were lean (BMI SDS

Schlagworte

Diabetologie und Stoffwechsel