Ultra-high resolution 1M array CGH analysis detects no formerly unknown aberration of 17q unaltered neuroblastomas

Background: Additional chromosomal material on the long arm of chromosome 17 (17q gain) is present in the vast majority of neuroblastomas (NB). Therefore it has been discussed as a first hit in the pathogenesis. In a previous aCGH analysis of 202 NB patients with a resolution of up to 15kb, we found a small group of patients (7%) without alterations of 17q, but with a poor prognosis. We now reinvestigated this subgroup with ultra-high-resolution arrays. Methods: Twelve tumors were analyzed by 1M aCGH with a median resolution of 2kb. Aberrations of 1p and MYCN were additionally analyzed by FISH. Ten tumors were a…