Factors associated with indeterminable results of interferon gamma release assay (IGRA) in routine screening for latent tuberculosis (LTB) in patients with inflammatory bowel dise…

Introduction: Screening for LTB including tuberculin skin test (TST), chest X-ray and facultatively, a whole blood interferon gamma release assay (IGRA) is mandatory in patients with IBD before starting therapy with Tumor Necrosis Factor (TNF) alpha inhibitors. However, being the more specific test method, IGRA might be limited in subjects under IM therapy due to a substantial number of indeterminable results. Aims and Methods: We aimed to evaluate factors such as laboratory findings and disease specific data which are associated with indeterminable IGRA (QuantiFERON®) results from logistic regressions on a coho…