Characterization of pancreatic and extrapancreatic polyamine homeostasis in l-ornithine-induced acute pancreatitis in rats

Introduction: L-ornithine is a precursor of polyamine synthesis that is essential for cell survival. However, intraperitoneal (i.p.) administration of L-ornithine results in severe acute necrotizing pancreatitis in rats. Aims: To investigate the changes in pancreatic and extrapancreatic (lung and liver) polyamine homeostasis after injection of a large dose of L-ornithine and to test the effects of the stable polyamine analogue methylspermidine (MeSpd) on L-ornithine-induced acute necrotizing pancreatitis. Methods: Male Wistar rats were injected intraperitoneally (i.p.) with 3g/kg L-ornithine and/or physiological…