Antigenome of Helicobacter pylori: vaccination on the horizon?
Z Kovács, A Meinke, E Nagy, T Henics, D Gelbmann, S Prustomersky, D Minh, B Winkler, U Stierschneider, M Berger, A von Gabain, M Storm, L Engstrand, B Hunyady · Zeitschrift für Gastroenterologie · 2010 · Heft 05
Bibliografische Angaben
Zusammenfassung
Helicobacter pylori is the most prevalent human pathogen with about 50% of the world's population infected. Although, it remains silent in most individuals for lifetime, colonization may develop into severe gastric and duodenal conditions, such as peptic ulcer disease and gastric adenocarcinoma. Rapidly developing resistance to current antibiotic-based treatment regimes urgently calls for the development of effective vaccines. In these studies we determined the comprehensive antigenic profile (so called “ANTIGENome“) of two clinical isolates of H. pylori, KTH-Ca1 and KTH-Du that were derived from patients with g…
