A common variant at the TERT-CLPTM1L locus modulates genetic risk of bile duct cancer
V Zimmer, F Mihalache, A Höblinger, F Grünhage, M Krawczyk, B Diaconu, BC Gärtner, M Acalovschi, T Sauerbruch, F Lammert · Zeitschrift für Gastroenterologie · 2010 · Heft 08
Bibliografische Angaben
Zusammenfassung
Background & Aim: Risk genes for bile duct cancer (BDC) are poorly defined (Höblinger A, Curr Opin Gastroenterol 2008). In a recent genome-wide association (GWA) study, the common variants at the TERT-CLPTM1L locus [telomerase reverse transcriptase (TERT), cisplatin resistance related protein CRR9p (CLPTM1L)]rs401681 and rs2736098, potentially affecting telomere length, have been implicated in the genetic predisposition to multiple solid tumors, however, not including cholangiocarcinoma (Rafnar T, Nat Genet 2008). In this study, we assessed these variants in a large European BDC cohort. Patients & Methods: We re…
