The role of cytochrome P-4502E1 in the progression of alcoholic and non-alcoholic fatty liver
H Qin, K Glassen, G Millonig, KB Linhart, H Bartsch, X Wang, V Buko, S Mueller, HK Seitz · Zeitschrift für Gastroenterologie · 2010 · Heft 08
Bibliografische Angaben
Zusammenfassung
Aims: Although the pathogenesis of alcoholic liver disease (ALD) is still unclear, there is increasing evidence of the involvement of cytochrome P-4502E1 (CYP2E1) in its progression, since the inhibition of CYP2E1 in animal experiments prevents ALD. The purpose of this study was to further investigate the role of CYP2E1 in hepatic steatosis, fibrosis and carcinogenesis in human livers and various animal models. Methods: The degree of fat, fibrosis and CYP2E1 induction was determined in liver biopsies from 60 patients with various stages of ALD and 40 patients with non alcoholic fatty liver disease (NAFLD). In ad…
