Transfemoral pulmonary valve replacement: tissue engineered valved stent implantation
J Boldt, UA Stock, T Hümme, G Fischer, J Cremer, A Metzner, G Lutter · RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren · 2010 · Heft 11
Bibliografische Angaben
Zusammenfassung
Objective: Tissue engineered valved stents might pursued to overcome calcification as the present limitation of bioprosthetic valves. Methods: Endothelial cells (EC) and autologous myofibroblasts (MF) were obtained from carotid artery segments of juvenile sheep. After the following MF-seeding, constructs were placed in a dynamic bioreactor system and cultured for 16 days. After EC seeding, tissue engineered valved stents were deployed into the pulmonary artery by angiography. The size of the stent was controlled by angiography, CT, and echo at the time of implantation and explantation (4 weeks). Constructs were…
