The Cyclin-dependent kinase 2 (Cdk2) is dispensable for liver regeneration in mice

The liver has the unique capability to regenerate from injury due to compensatory proliferation of remnant hepatocytes. For this process, hepatocytes leave their quiescent state and re-enter the cell cycle until the original liver mass is restored. Cyclin-dependent kinase 2 (Cdk2) is an important cell cycle mediator driving S-phase initiation and cell cycle progression via complex formation with E- and A-type cyclins, respectively. The aim of the study was to evaluate the role of Cdk2 for liver regeneration. Hepatocyte-specific Cdk2 knockout mice (Cdk2Δhepa) and wild type (WT) controls were subjected to partial…