The common adiponutrin variant p.I148M, a genetic risk factor for non-alcoholic fatty liver disease, affects fasting glucose and triglyceride levels

Aims: Last year we reported that the common adiponutrin (PNPLA3) coding polymorphism p.I148M, a genetic determinant of severe forms of non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD), does not increase the risk of developing gallstones (1). To date, studies on the effect of the adiponutrin variant on lipid and glucose metabolism remain controversial (2,3). Here our aim was to assess whether the PNPLA3 polymorphism p.I148M affects glucose and lipid levels in a general population. Patients and methods: We recruited 229 individuals with gallstones (confirmed by ultrasound or cholecystect…