Epithelial mesenchymal Transition (EMT) associated transcription factor Goosecoid is highly expressed in human hepatocellular carcinoma (HCC)
JM Schlagheck, P Godoy, G Campos, R Stöber, JG Hengstler, R Vogt, M Melter, TS Weiss · Zeitschrift für Gastroenterologie · 2011 · Heft 01
Bibliografische Angaben
Zusammenfassung
More than one million new cases of hepatocellular carcinoma (HCC) are reported per year. Furthermore HCC is the fifth common cancer in the world, while it is the third common cause of death in cancers. The aim of our work was to test the hypothesis that EMT and involved transcription factors play a role in the development of hepatocellular cancer. The transcription factor Goosecoid has been described to be associated with EMT and was increased in carcinomas with a high metastatic potency. Therefore we analyzed expression of Goosecoid, Twist and SNAIL in human HCC. Total RNA was isolated from biopsies of human HC…
