Western-diet enhances expression of death receptors and fatty acid transporters in a mouse model of 70% hepatectomy and leads to increased cell proliferation in the liver

Aims: The non-alcoholic fatty liver disease (NAFLD) is associated with excessive lipid-droplet accumulation in hepatocytes, increased death-receptor expression, altered apoptosis-induction and may progress to liver damage and fibrosis. Active transport of free fatty acids (FFA) is thought to participate in liver cell damage and enhanced apoptosis sensitivity. Death Receptors (DR) apart from apoptosis signalling, also initiate cell proliferation. Thus we investigated, whether high fat diet (HFD) has an impact on apoptosis or regeneration after hepatectomy. Methods: C57Bl/6J-mice received standard (SD) or HFD for…