Different cell death mechanisms are triggered by acute or chronic right heart failure-induced liver failure

Background and Aims: Heart failure is a major issue in cardiologic patients and surgical interventions which can lead to liver failure (LF). The prognosis of LF due to right heart failure (RHF) depends on various factors like age of the patient, comorbidities, BMI and amount of cell death within the liver. However, course of liver failure and prognosis are hard to predict. The cytokeratin-18 (CK18) epitopes M65 and M30 are reported to distinguish between overall (necrotic) and apoptotic cell death, respectively. We investigated whether these cell death markers predict outcome of patients with RHF-induced LF and…