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Exudate macrophages attenuate lung injury by the release of IL-1 receptor antagonist in gram-negative pneumonia

S Herold, T Shafiei Tabar, H Janßen, K Högner, W Seeger, M Steinmüller, J Lohmeyer · Pneumologie · 2011 · Heft 03

Dokument
1016300
CareLit-ID
Jahr
2011
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Pneumologie
Autor:innen
S Herold, T Shafiei Tabar, H Janßen, K Högner, W Seeger, M Steinmüller, J Lohmeyer
Ausgabe
Heft 03 / 2011
Seiten
–
Erschienen: 2011-03-10 00:00:00
ISSN
0934-8387
DOI
10.1055/s-0031-1272254

Zusammenfassung

Exudate macrophages are key players in host defense towards invading pathogens. Their anti-inflammatory and epithelial-protective potential in gram-negative pneumonia, however, remains elusive. Objective: We investigated whether exudate macrophages contributed to preservation of alveolar epithelial barrier integrity and analyzed the molecular pathways involved. Methods: We evaluated the anti-inflammatory and epithelial-protective effects of exudate macrophages in a model of LPS- and K. pneumoniae-induced lung injury comparing wild-type and CCR2 (CC-chemokine receptor 2)-deficient mice with defective lung macroph…

Schlagworte

Apoptosis Acute Lung Injury Adoptive Transfer Chemokine Blood After Pneumologie