Superoxide generation by NOX1 contributes to abnormal migration and proliferation of pulmonary arterial smooth muscle cells in rats
F Veit, M Roth, B Egemnazarov, M Seimetz, HA Ghofrani, RT Schermuly, W Seeger, F Grimminger, N Weissmann · Pneumologie · 2011 · Heft 03
Bibliografische Angaben
Zusammenfassung
Rationale: Chronic alveolar hypoxia induces pulmonary hypertension (PH), concomitant with pulmonary vascular remodeling. Reactive oxygen species (ROS) are thought to play a major role in this process. Our recent findings suggest that ROS production by NAD(P)H-oxidase 4 (NOX4) is important in this remodeling process. Objectives: We investigated whether similar mechanisms are true for non-hypoxia induced PH, namely PH induced by monocrotaline (MCT) in rats. The aim was to examine ROS production, their possible sources and their impact on cell function and signaling pathways. Furthermore we investigated the express…
