Basal ganglia oscillations during gait in Parkinsonian patients

Introduction: It has been observed that local field potential (LFP) oscillations in the 13–30Hz frequency band are related to the pathophysiology of the basal ganglia of Parkinson's disease. Here we hypothesized that these pathophysiological oscillations modulate during gait in Parkinson's disease where subjects have freezing and non-freezing phenomenon. Method: To this end we recorded LFPs from deep brain stimulation electrodes implanted into the subthalamic nucleus of Parkinson patients during rest and gait on a treadmill machine. Parkinson patients were grouped into subjects with freezing (i) and subjects wit…