Postural assessement in dynamic posturography – a useful motor phenotype measure for presymptomatic and manifest Huntington disease?

Background: Objective assessment of balance control in dynamic posturography (DP) may be helpful to assess motor phenotype in premanifest (pHD) and symptomatic (sHD) Huntington's Disease (HD). HD patients are known to develop a decline of balance that results in a high risk of falls. Aim: To investigate whether DP using a mobile platform (one degree of freedom, anterior-posterior) is able to detect a motor phenotype in pHD and sHD and to assess whether these measures correlate to the severity of disease as assessed by the UHDRS-TMS, DBS (Disease Burden Score), CS (Cognitive Score), FAS (Functional Assessment Sco…