A high-throughput drug-screen for new therapies in cystic kidney disease using a zebrafish model system

Aims: Cystic kidney disease is a common cause of chronic renal failure in children and adults with autosomal-dominant polycystic kidney disease (ADPKD) being a lot more common than autosomal-recessive polycystic kidney disease (ARPKD). Several syndromic diseases such as Meckel-Gruber-Syndrome and Bardet-Biedl-Syndrome are associated with cystic kidneys as well as Nephronophthisis/ Joubert-syndrome. Together, these diseases represent a significant health and economic burden and so far, depsite several promising approaches in mice using m-Tor inhibitors, CFTR-inhibitors, Vasopressin-inhbitors or TNF-alpha blockers…