CareLit Fachartikel

Enhancing the performance of GFR prediction equations in children by combining a cystatin C-based with a creatinine-based equation

H Blufpand, G Kaspers, F Abbink, A Bökenkamp · Klinische Pädiatrie · 2011 · Heft 03

Dokument
1016392
CareLit-ID
Jahr
2011
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Klinische Pädiatrie
Autor:innen
H Blufpand, G Kaspers, F Abbink, A Bökenkamp
Ausgabe
Heft 03 / 2011
Seiten
–
Erschienen: 2011-03-23 00:00:00
ISSN
0300-8630
DOI
10.1055/s-0031-1273874

Zusammenfassung

Introduction: Estimates of glomerular filtration rate (GFR) are considered the best overall indices of kidney function. Exceptional dietary intake or muscle mass hampers the use of creatinine-based estimating equations, whereas cystatin C-based equations are affected by steroid therapy. Combining a creatinine-based with a cystatin C-based equation may improve prediction of GFR in children. Methods: In 331 children, GFR was estimated using the creatinine-based Schwartz equation (eGFRcrea) and the cystatin C-based Filler equation (eGFRcys). In addition GFR was measured by single-injection inulin clearance as gold…

Schlagworte

creatinine cystatin C glomerular filtration rate kidney function Bias Klinische Pädiatrie