IKZF1 deletion is an independent predictor of outcome in pediatric acute lymphoblastic leukemia treated according to the ALL-BFM 2000 protocol
P Breithaupt, B Meissner, M Zimmermann, A Möricke, A Schrauder, J Harbott, WD Ludwig, R Köhler, CR Bartram, M Schrappe, G Cario, M Stanulla · Klinische Pädiatrie · 2011 · Heft 05
Bibliografische Angaben
Zusammenfassung
Introduction: Alteration of the IKZF1 gene has been associated with a poor outcome in pediatric precursor B-cell acute lymphoblastic leukemia (ALL). Method: To assess the prognostic value of IKZF1 deletions we screened a representative cohort of 409 pediatric ALL patients treated on the German ALL-BFM 2000 study protocol, by multiplex ligation-dependent probe amplification (MLPA). Results: Patients with IKZF1 deletion had a significantly lower 5-year event-free survival (EFS) compared to not-deleted patients, due to a higher cumulative incidence of relapses. IKZF1 deletion conferred a risk of 2.4 for an event wh…
