Secondary mutations in t(4;11) leukemia

Introduction: Due to recent findings, demonstrating the adverse effects of mutated FLT3 for t(4;11) leukemic cells (Furuichi et al., 2007), we got interested in analyzing a larger cohort of t(4;11) patients for their spectrum of secondary mutations. For the purpose of our study, we used isolated genomic DNA from biopsy material that was collected at diagnosis from t(4;11) patients (n=100). Our cohort was splitted into three 3 different subgroups separating „childhood leukemia“ (n=31) from „adult leukemia“ cases (n=48) and from patients that suffered from „complex rearrangements“. Within the latter group MLL, AF4…