Angiotensin AT2R stimulation improves glucose tolerance and insulin sensitivity in obese mice
S Wardat, M Iwai, M Horiuchi, B Dahlöf, A Hallberg, T Unger, U Kintscher, UM Steckelings, A Foryst-Ludwig · Diabetologie und Stoffwechsel · 2011 · Heft 05
Bibliografische Angaben
Zusammenfassung
Objective: The functional role of the AT1-receptor (AT1R) in the development of insulin-resistance (IR) is well understood and it is known that AT1R-blockers (ARBs) improve glucose-intolerance and IR. The metabolic contribution of the AT2-receptor (AT2R) is still controversial. Thus, this study aimed to determine the functional significance of the AT2R for the development of IR and adipose-tissue inflammation using the first non-peptide AT2R-agonist, Compound 21 (C21). Design and methods: Wild type (WT; C57Bl-6) and AT2R-knockout (AT2R-KO) mice were fed with high fat diet (HFD) or control low fat diet (LFD) (60%…
