Dietary fibres reduce diabetes prevalence in NZO mice independently of obesity development
D Kaiser, S Scherneck, N Becker, HBH Mabrok, G Loh, A Schürmann, HG Joost, P Wiedmer · Diabetologie und Stoffwechsel · 2011 · Heft 05
Bibliografische Angaben
Zusammenfassung
Introduction: Epidemiological studies provide evidence for a correlation between an increased intake of fibre-rich whole-grain cereals and a reduced diabetes risk. The underlying mechanism is unknown. The aim of this study was to identify possible mechanisms of action by feeding diets enriched with different fibre types, e.g. soluble and insoluble fibres. New Zealand Obese (NZO) mice, which develop obesity-dependent diabetes with beta-cell failure, were used as a polygenic type 2 diabetes model. Methods: Up to 16 weeks of age, male NZO mice were fed with high-fat diets (15% fat w/w) containing different amounts…
