Molecular targets in antimetastatic therapy of gastrointestinal tumors

For the control of gastrointestinal tumor metastasis it is important to identify chemical compounds with antimigratory potency. Agents acting against single cell and cluster type migration are necessary for successful antimetastatic therapy. In the present study, the migration of tumor cells was compared in a Boyden chamber and in an extracellular matrix based three-dimensional cell culture (3-DCC) model system. The Boyden chamber offers a model of single tumor cell migration, whereas the 3-DCC model system demonstrates invasive growth in the form of a cluster. Our study provided evidence that certain cytotoxic/…