High prevalence of red blood cell alloantibodies in patients with inflammatory bowel disease – a prospective study
P Papay, K Hackner, H Vogelsang, G Novacek, C Primas, W Reinisch, A Eser, A Mikulits, WR Mayr, GF Körmöczi · Zeitschrift für Gastroenterologie · 2011 · Heft 05
Bibliografische Angaben
Zusammenfassung
Background and aim: Inflammatory bowel disease (IBD) is associated with chronic anemia which, upon disease exacerbation or intestinal surgery, may necessitate allogenic blood transfusion (ABT). However, ABT and pregnancy may induce red blood cell alloantibodies (RBCA), with the potential to complicating further ABTs and pregnancies. Recent evidence suggests that inflammation may escalate RBCA formation; therefore, the prevalence and clinical modulators of RBCA acquisition were studied in IBD patients. Design: Clinical data including RBCA status of 193 consecutive IBD patients with a history of ABT and/or pregnan…
