Specific therapeutic targeting of malignancies of the liver by transient depletion of adenosine triphosphates
T Weiland, K Klein, M Zimmermann, T Speicher, S Venturelli, A Berger, H Bantel, A Königsrainer, M Schenk, TS Weiss, A Wendel, M Schwab, M Bitzer, UM Lauer · Zeitschrift für Gastroenterologie · 2011 · Heft 08
Bibliografische Angaben
Zusammenfassung
Background & aims: Despite its high potency, TNF's current use in medical oncology is restricted since effective doses leading to profound hepatotoxicity. Interestingly, TNF-induced cytotoxicity is known to be a highly ATP-dependent process. In primary murine hepatocytes it was recognized that fructose transiently depletes ATP which is due to a distinct enzyme configuration being specific for hepatocytes leading to a TNF resistance (Speicher et al., 2010). In light of the murine results, the goal of our current study was to find out whether the therapeutic benefits of fructose also apply to the human situation.…
