CareLit Fachartikel
A novel suicide gene-expressing oncolytic measles vaccine virus for the treatment of hepatocellular carcinoma
J Lampe, S Bossow, I Smirnow, T Weiland, WJ Neubert, M Bitzer, UM Lauer · Zeitschrift für Gastroenterologie · 2011 · Heft 08
Dokument
1016961
CareLit-ID
Jahr
2011
Publikation
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nein
Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
Introduction: Despite tremendous efforts in the search for new therapies, a truly efficient cure for hepatocellular carcinoma (HCC) is not available. Oncolytic viruses are promising agents under investigation as new cancer therapeutics. These replication competent viruses selectively infect and kill cancer cells. To enhance cell killing, oncolytic viruses can be engineered to express suicide genes which convert non-toxic substances (prodrugs) into toxic metabolites. Aims: Development of new anti-HCC regimens based on oncolytic measles vaccine virus (MeV) expressing functionally optimized suicide genes. Methods:…
Schlagworte
Cytosine Deaminase
Bystander Effect
Bystander-Effect
Cytosine
Tumor
Zeitschrift für Gastroenterologie
