Pathogenetic therapy of genital endometriosis
MI Yarmolinskaya, AS Molotkov, VV Rulev · Geburtshilfe und Frauenheilkunde · 2011 · Heft 11
Bibliografische Angaben
Zusammenfassung
Understanding important role of immune system in the development of genital endometriosis has outlined new ways of studying pathogenesis of the disease and new approaches to treatment strategies. Alterations of antiproliferative components of immune system (reduction of cytotoxic activity of NK cells in peripheral blood and peritoneal fluid and loss of ability of leukocytes in peripheral blood to produce IFN-α/β and IFN-γ) are marked as a mechanism of development of endometriosis. We revealed the rise of the amount of peritoneal macrophages and proinflammatory cytokines and chemokines in peritoneal fluid and in…