CareLit Fachartikel
Oxidative stress as antifibrogenic stimulus? Low dose steady state H2O2 induces fibrolytic MMP–3 in vitro and in vivo
G Millonig, S Ottinger, HK Seitz, S Mueller · Zeitschrift für Gastroenterologie · 2012 · Heft 01
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1017169
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Jahr
2012
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Zusammenfassung
Introduction: Inflammation associated oxidative stress such as H2O2 is considered a key event during development of fibrosis/cirrhosis. This contrasts with other fibrogenic diseases such as rheumatoid arthritis where inflammation has been incriminated in opposing effects such as fibrolytic activity and cartilage destruction. We here study the effect of sustained low H2O2 levels on fibroblasts and hepatic stellate cells and in a mouse model. Methods: Human NIH 3T3 fibroblasts and LX–2 hepatic stellate cells were incubated for 6 or 24h with 0.5–6µM H2O2 using the recently developed GOX/CAT system (enzymatic genera…
Schlagworte
H2O2
MMP3
antifibrotic therapy
fibrolysis
fibrosis
oxidative stress
Zeitschrift für Gastroenterologie
