Intestinal inflammation induces alterations in enterohepatic Fgf15 signalling, changes in hepatic bile acid metabolism and a “toxic bile” composition in DSS-treated mice
M Rau, B Stieger, J Schmitt, K Leucht, A Cee, A Al-Debi, JJG Marin, MJ Monte, B Müllhaupt, G Rogler, A Geier · Zeitschrift für Gastroenterologie · 2012 · Heft 01
Bibliografische Angaben
Zusammenfassung
Aims: Primary sclerosing cholangitis is a chronic cholestatic liver disease affecting intra- and extrahepatic bile ducts frequently associated with inflammatory bowel disease. The pathogenetic pathway leading from intestinal inflammation to cholestatic liver disease is still poorly understood. Aims: To study alterations in enterohepatic Fgf15 signalling and associated changes in hepatic gene expression and bile composition in murine colitis. Methods: Fgf15 pathway target genes in gut and liver of DSS-treated mice (7d, 2% DSS in drinking water) and control mice were quantified by RT-PCR. Changes of bile acid tran…
