Concomitant immunological diseases in primary sclerosing cholangitis are a risk factor for reduced survival

Background & Aims: Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease that can be rather defined as an immune-mediated disease than a classical autoimmune disease. Association with other immunological diseases like inflammatory bowel disease (IBD) and autoimmune hepatitis (AIH) is well known. We evaluated the presence of immunological disease beside IBD and AIH in a German cohort of PSC patients and performed a concise differentiation between classical autoimmune (AID) and immune-mediated inflammatory diseases (IMID) and report its influence on clinical outcome. Methods: Cohort study of…