CareLit Fachartikel
Distinct functions of the MAPKAP kinases MK2 and MK3 in the regulation of the inflammatory response in macrophages
C Ehlting, N Ronkina, M Gaestel, D Häussinger, JG Bode · Zeitschrift für Gastroenterologie · 2012 · Heft 01
Dokument
1017183
CareLit-ID
Jahr
2012
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
The liver is highly exposed to foreign, in particular gut-derived material and as an important immune organ it harbours the bodies’ largest pool of macrophages, which are predominantly located in the periportal area to screen infiltrating pathogens. In macrophages the bacterial component lipopolysaccharide (LPS) induces the expression of pro- and anti-inflammatory target genes. A tightly controled induction of these target genes is important to prevent severe hepatocyte damage due to an overwhelming inflammatory response. p38MAPK-mediated activation of MK2 and MK3 is essential for the production and the control…
Schlagworte
cytokines
inflammation
interferon
macrophages
signal transduction
Zeitschrift für Gastroenterologie
