CareLit Fachartikel
HBsAg-specific humoral and cellular immune responses in children and adolescents 8–14 years after vaccination against hepatitis B
B Huber, JJ Wenzel, U Leisner, W Jilg · Zeitschrift für Gastroenterologie · 2012 · Heft 01
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1017184
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Jahr
2012
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Zusammenfassung
In 1995, universal hepatitis B vaccination of infants was established in Germany. In this pilot study we examined antibody concentrations to hepatitis B surface antigen (anti-HBs) in children and adolescents 8–14 years after basic immunisation. Participants with anti-HBs concentrations lower than 10 IU/l received a booster vaccination. On the day of revaccination and 10 days later blood samples were taken and lymphocytes were isolated for analysis of cellular immunity. Furthermore, the humoral immune response was also analysed on day 10 after revaccination. Of the 285 children and adolescents enrolled in the stu…
Schlagworte
HBV
IFNgamma
IL-5
adolescents
cellular immune response
fluorospot
humoral immune response
infants
revaccination
vaccination
Zeitschrift für Gastroenterologie
