Hepatic stellate cells veto CD8 T cell activation by a CD54-dependent mechanism
F Schildberg, B Höchst, A Wojtalla, SV Siegmund, E Endl, L Diehl, Z Abdullah, C Kurts, PA Knolle · Zeitschrift für Gastroenterologie · 2012 · Heft 01
Bibliografische Angaben
Zusammenfassung
The role of the liver in T cell tolerance is mainly achieved via the functions of tolerogenic hepatic antigen-presenting cells (APCs) and regulatory T cells. Of particular interest in these experiments, hepatic stellate cells (HSCs) have been documented to possess multiple immune functions, ranging from immunogenic antigen presentation to induction of T cell apoptosis. Here, we demonstrate a novel characteristic of stellate cells: the vetoing of naive CD8 T cell priming. The activation of naive T cells by dendritic cells, artificial APCs or PMA/Ionomycin was prevented via a cell contact-dependent mechanism. This…
