Specific therapeutic targeting of liver malignancies by transient depletion of adenosine tri-phosphates
W Timo, K Klein, M Zimmermann, T speicher, S Venturelli, A Berger, H Bantel, A Königsrainer, M Schenk, TS Weiss, A Wendel, M Schwab, NP Malek, M Bitzer, UM Lauer · Zeitschrift für Gastroenterologie · 2012 · Heft 01
Bibliografische Angaben
Zusammenfassung
Background & Aims: The current use of TNF in medical oncology is restricted since effective doses lead to profound hepatotoxicity. Interestingly, TNF-induced cytotoxicity is known to be a highly ATP-dependent process. In primary murine hepatocytes it was recognized that fructose transiently depletes ATP leading to a TNF resistance (Speicher et al., 2010). In light of the results obtained in the murine system, the goal of our current study was to find out whether the therapeutic benefits of fructose also apply to the human situation. Methodology: By investigating human GI- tumor cell lines, primary human hepatocy…
