4-aminopyridine improves cerebellar tremor in a patient with multiple sclerosis

The reversible potassium channel blocker 4-aminopyridine (4-AP) effectively improves gait performance in patients with multiple sclerosis (MS). Moreover, 4-AP alleviates cerebellar gait disorders by reducing the magnitude of gait variability. Here, we report on a novel effect of 4-AP that efficiently reduced cerebellar tremor in a patient with multiple sclerosis. A 44 years old woman with a progredient form of MS was treated with 5mg of 4-AP t.i.d. The Expanded Disability Status Scale (EDSS) was 6.5 with the leading symptoms of gait disturbance and cerebellar intention and holding tremor. Gait performance and tr…