CareLit Fachartikel

The JARID1C histone demethylase is upregulated in aggressive neuroblastomas independent of MYCN amplification

K Fielitz, B Schowe, JH Schulte, J Vandesompele, P Mestdagh, A Eggert, K Morik, A Schramm · Klinische Pädiatrie · 2012 · Heft 04

Dokument
1017592
CareLit-ID
Jahr
2012
Publikation
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Klinische Pädiatrie
Autor:innen
K Fielitz, B Schowe, JH Schulte, J Vandesompele, P Mestdagh, A Eggert, K Morik, A Schramm
Ausgabe
Heft 04 / 2012
Seiten
–
Erschienen: 2012-04-27 00:00:00
ISSN
0300-8630
DOI
10.1055/s-0032-1310494

Zusammenfassung

Aims: Defining reliable risk factors for progression and outcome in advanced stage neuroblastoma (NB) patients not harboring a MYCN amplification is still challenging. Methods: Expression profiles were generated from 113 primary NBs on Affymetrix microarrays. Genes associated with patient outcome but independent of known risk factors were identified using correlation analysis. Results: Expression of JARID1C was significantly elevated in primary NBs from patients who later suffered relapse, independent of MYCN amplification status. The JARID1C protein was detectable in all NB cell lines analyzed. Cell viability a…

Schlagworte

Klinische Pädiatrie